In the last 10 years, there has been a trend toward the implementation of conformal, minimally invasive and tissue conserving interventions. This is shown by the growing number of image-guidance systems found in the operating rooms and radiation therapy centres.
In oncology, accurate visualization of tumor, critical healthy tissues and their boundaries during a therapeutic intervention remains an unresolved challenge.
This can be effectively addressed by the introduction of an injectable imaging agent that enhances target structures in multiple imaging modalities (i.e. CT, MR, optical) over a prolonged time window. This allows for contrast-enhanced pre- and intra-interventional imaging to be performed using the desired imaging modalities following a single injection.
The image-guided surgery agent CF800 (Figure 1) is currently being advanced for Phase I/II trials at Princess Margaret Cancer Centre for Health Canada Approval.